반응 #959481

반응 방정식

5-(4-phenylacetyl-phenyl)-2-oxa-4-aza-bicyclo[3.1.1]heptan-3-one

pyridinium hydrobromide

→

crude title compound

5-[4-(2-bromo-2-phenyl-acetyl)-phenyl]-2-oxa-4-aza-bicyclo[3.1.1]heptan-3-one

용매

THF

반응 조건

후처리

1. 1
   기타The mixture was partitioned between EtOAc and water
2. 2
   세척the organic phase washed successively with dilute aqueous sodium thiosulfate and brine
3. 3
   기타dried
4. 4
   농축concentrated

실험 절차

A mixture of 5-(4-phenylacetyl-phenyl)-2-oxa-4-aza-bicyclo[3.1.1]heptan-3-one (2.34 g) and pyridinium hydrobromide perbromide (2.22 g) in THF (39 mL) was stirred at rt for 2 hours. The mixture was partitioned between EtOAc and water and the organic phase washed successively with dilute aqueous sodium thiosulfate and brine, dried and concentrated to give the crude title compound which was used in the next step without further purification.

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