반응 #958987
ord-524d0fc7659e4a88a3c370b640756461
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반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1여과The precipitate was collected by filtration
- 2세척washed with water
- 3기타The solid was dried in an oven at 120° C. overnight
실험 절차
2.03 g sodium alendronate trihydrate (6.25 mmol) and 6.9 g sodium tripolyphosphate, Na5P3O10 were added to 100 mL water, and the mixture was stirred until all dissolved. 10.34 g calcium chloride dihydrate were dissolved in 200 mL water. The calcium chloride solution was heated to 40° C. and the pH was adjusted to 7.0. The alendronate-tripolyphosphonate solution was added into the calcium chloride solution dropwise, keeping the pH of the resulting solution at 7.0 by adding 1N NaOH. The precipitate was collected by filtration and washed with water. The solid was dried in an oven at 120° C. overnight. 8.82 g of calcium complex salt of alendronate with tripolyphosphate was thus obtained.