반응 #957261

반응 방정식

(E)-3-[1-(toluene-4-sulfonyl)-1H-pyrrol-3yl]-acrylic acid tert-butyl ester

compound C1

(E)-3-[1-(toluene-4-sulfonyl)-1H-pyrrol-3yl]-acrylic acid tert-butyl ester

trifluoroacetic acid

→

title compound

수율 70.9%

(E)-3-[1-(Toluene-4-sulfonyl)-1H-pyrrol-3yl]-acrylic acid

수율 70.9%

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The solvent is evaporated to dryness and to the residue
2. 2
   workup.ADDITIONare added 30 ml of water
3. 3
   추출The water phase is extracted exhaustively with ethyl acetate
4. 4
   건조Then the organic phase is dried over sodium sulfate
5. 5
   기타The filtrate is evaporated
6. 6
   기타dried under vacuo

실험 절차

1.60 g of (E)-3-[1-(toluene-4-sulfonyl)-1H-pyrrol-3yl]-acrylic acid tert-butyl ester (compound C1) are dissolved in 70 ml of dichloromethane at ambient temperature. Then 7 ml of trifluoroacetic acid (TFA) are added and stirred for 4 hours. The solvent is evaporated to dryness and to the residue are added 30 ml of water. The water phase is extracted exhaustively with ethyl acetate. Then the organic phase is dried over sodium sulfate. The filtrate is evaporated and dried under vacuo to give 0.951 g of the title compound as a pale grey solid.

출처