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9-Bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline

benzene boronic acid

→

1-(2-methylpropyl)-9-phenyl-1H-imidazo[4,5-c]quinoline

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후처리

1. 1
   기타The crude product was purified by HPFC (
2. 2
   세척eluting with chloroform

실험 절차

9-Bromo-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline (0.34 mmol) and benzene boronic acid (62 mg, 0.51 mmol) were coupled according to Part J of Example 1. The work-up procedure described in Parts 125–135 was followed. The crude product was purified by HPFC (eluting with chloroform:CMA in a gradient from 100:0 to 85:15) to provide 1-(2-methylpropyl)-9-phenyl-1H-imidazo[4,5-c]quinoline.

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