반응 #9570

반응 방정식

5-[(3-Bromophenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione

→

7-bromoquinolin-4-ol

5-bromoquinolin-4-ol

용매

DOWTHERM A

반응 조건

후처리

1. 1
   온도heat transfer fluid for one hour
2. 2
   기타A precipitate formed
3. 3
   온도upon cooling
4. 4
   기타was isolated by filtration
5. 5
   세척washed with diethyl ether

실험 절차

5-[(3-Bromophenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (32.6 g, 0.100 mol) was heated at 250° C. in DOWTHERM A heat transfer fluid for one hour, and then the reaction was allowed to cool to ambient temperature. A precipitate formed upon cooling and was isolated by filtration and washed with diethyl ether to provide 7-bromoquinolin-4-ol and 5-bromoquinolin-4-ol in a 2:1 ratio.

출처