반응 #95677
ord-87a3a592b65443759832102a9c1a8ecf
반응 방정식
용매
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타(ca 2.5 hours)
- 2온도After cooling
- 3기타removal of the unreacted 6-fluoro-2-nitrotoluene
- 4추출by extraction with ethyl acetate
- 5추출extracted three times with ethyl acetate
- 6건조The combined organic extracts are dried over magnesium sulphate
- 7농축concentrated
실험 절차
A mixture of 34.5 g (0.22 mol) of 6-fluoro-2-nitrotoluene, 30.7 g (0.22 mol) of potassium carbonate, 105.4 g (0.66 mol) of potassium permanganate and 3.3 liters of water is heated at 100° C. until the permanganate is decolorised (ca 2.5 hours). After cooling and removal of the unreacted 6-fluoro-2-nitrotoluene by extraction with ethyl acetate, the aqueous phase is adjusted to pH 1 with hydrochloric acid and extracted three times with ethyl acetate. The combined organic extracts are dried over magnesium sulphate and concentrated, there being obtained 6-fluoro-2-nitrobenzoic acid. After recrystallisation from ethyl acetate/n-hexane, the product melts at 146°-148° C.