반응 #9560

반응 방정식

(7-Bromo-3-nitroquinolin-4-yl)-(2-methylpropyl)amine

→

7-bromo-N4-(2-methylpropyl)quinoline-3,4-diamine

용매

toluene

toluene

반응 조건

후처리

1. 1
   기타The vessel was evacuated
2. 2
   workup.ADDITIONcharged with hydrogen (54 psi, 3.7×105 Pa)
3. 3
   기타The reaction mixture evacuated
4. 4
   여과filtered through a layer of CELITE
5. 5
   여과filter aid
6. 6
   농축concentrated under reduced pressure

실험 절차

(7-Bromo-3-nitroquinolin-4-yl)-(2-methylpropyl)amine (117 g) was dissolved in hot toluene (2 L) and poured into stainless steel Parr vessel. Additional toluene (2 L) and 5% platinum on carbon (12.5 g) were added. The vessel was evacuated, charged with hydrogen (54 psi, 3.7×105 Pa), and shaken overnight at room temperature. The reaction mixture evacuated, filtered through a layer of CELITE filter aid, and concentrated under reduced pressure to provide 7-bromo-N4-(2-methylpropyl)quinoline-3,4-diamine, which was used without purification.

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