반응 #956

반응 방정식

1-benzyloxycarbonylamidino-4-mesyloxyethyl piperidine

sodium azide

water

→

4-Azidoethyl-1-benzyloxycarbonylamidino piperidine

용매

dimethylformamide

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   추출extracted with ethyl acetate three times
3. 3
   세척The combined organic phase was washed with water
4. 4
   건조dried (Na2SO4)
5. 5
   기타evaporated
6. 6
   기타chromatographed on silica gel

실험 절차

In 100 ml of dimethylformamide was dissolve (0.0115 mol) of crude 1-benzyloxycarbonylamidino-4-mesyloxyethyl piperidine and 4.5 g (0.069 mol) of sodium azide was added. The mixture was heated at 100° C. for 2.5 h. It was then poured into water and extracted with ethyl acetate three times. The combined organic phase was washed with water, dried (Na2SO4) and evaporated. The residue was flash chromatographed on silica gel using ethyl acetate/heptane 1/1 as eluent. Yield: 3.0 g (79%).

출처