반응 #955964

반응 방정식

1,3-Dibromo-5-(heptadecan-9-yl)-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione

ethanol

acetic acid

HCl

→

1-bromo-5-(heptadecan-9-yl)-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione

용매

CHCl3

hexane

반응 조건

후처리

1. 1
   온도Mixture was refluxed for one hour after which an aliquot
2. 2
   기타reaction
3. 3
   온도After cooling
4. 4
   여과the solution was filtered through fritted glass
5. 5
   기타was evaporated under vacuum
6. 6
   기타Product was obtained by silica chromatography

실험 절차

1,3-Dibromo-5-(heptadecan-9-yl)-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione (9.43 g, 20.04 mmol) and zinc (1.31 g, 20.04 mmol) were placed in a 3 neck round-bottom flask equipped with a water condenser with ethanol (130 mL), acetic acid (40 mL) and 1 M HCl (2.5 mL). Mixture was refluxed for one hour after which an aliquot was taken for NMR analysis, which indicated reaction was complete. After cooling, the solution was filtered through fritted glass to eliminate remaining Zn particles and solvent was evaporated under vacuum. Product was obtained by silica chromatography, using a 100% hexane to 100% CHCl3 gradient.

출처