반응 #955938

반응 방정식

4-chloro-2-methoxybenzoic acid

MeOH

→

methyl 4-chloro-2-methoxybenzoate

수율 96.0%

용매

H2SO4

반응 조건

후처리

1. 1
   온도was refluxed overnight
2. 2
   기타MeOH was evaporated
3. 3
   추출the residue was extracted to EtOAc
4. 4
   세척successively washed with water and brine
5. 5
   건조dried over MgSO4
6. 6
   여과filtered
7. 7
   기타evaporated

실험 절차

A suspension of 4-chloro-2-methoxybenzoic acid (5 g, 27 mmol) in MeOH (18 mL) and conc. H2SO4 (1.5 mL) was refluxed overnight. MeOH was evaporated and the residue was extracted to EtOAc and successively washed with water and brine, dried over MgSO4, filtered and evaporated to give methyl 4-chloro-2-methoxybenzoate as a white solid (5.17 g, 96%).

출처