반응 #955741

반응 방정식

isatin

2-diisopropylaminoethyl chloride hydrochloride

potassium carbonate

→

1-(2-diisopropylaminoethyl)isatin

수율 89.9%

용매

toluene

반응 조건

후처리

1. 1
   온도After cooling
2. 2
   세척the reaction mixture was washed with water
3. 3
   건조dried over anhydrous magnesium sulfate
4. 4
   농축concentrated under reduced pressure
5. 5
   기타The residue was recrystallized from hexane

실험 절차

A suspension of 2.94 g of isatin, 4.20 g of 2-diisopropylaminoethyl chloride hydrochloride, and 3.17 g of anhydrous potassium carbonate in 50 ml of toluene was stirred for 4 hours at 90° C. After cooling, the reaction mixture was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from hexane to obtain 4.93 g of 1-(2-diisopropylaminoethyl)isatin. The chemical properties of this product are identical with those of the product obtained by Reference Example 1.

출처