반응 #95557

반응 방정식

Cis 2-tribromoacetyl-3,3-dimethylcyclopropane carboxylic acid

sodium borohydride

→

4-dibromomethyl-6,6-dimethyl-3-oxabicyclo[3.1.0]hexan-2-one

용매

water

반응 조건

후처리

1. 1
   여과the crystalline reaction product was then filtered off
2. 2
   기타dried under reduced pressure at 40° C

실험 절차

Cis 2-tribromoacetyl-3,3-dimethylcyclopropane carboxylic acid (0.2 mmol) prepared by a method analogous to that described in Example 1, was stirred for 10 minutes with a solution of sodium borohydride (0.8 mmol) in 5 ml water at room temperature for 16 hours and the crystalline reaction product was then filtered off and dried under reduced pressure at 40° C. The resulting product weighed 13 mg and contained 50% of the desired product, largely in the form of the endo isomer.

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