반응 #9554

반응 방정식

1-amino-2-methylpropan-2-ol

7-benzyl-4-chloro-3-nitroquinoline

6-benzyl-4-chloro-3-nitroquinoline

triethylamine

→

1-(7-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

1-(6-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The volatiles were removed under reduced pressure
2. 2
   workup.STIRRINGthe residue was stirred with water (50 mL) for one hour
3. 3
   기타The resulting yellow solid was isolated by filtration
4. 4
   세척washed with water

실험 절차

Under a nitrogen atmosphere, 1-amino-2-methylpropan-2-ol (1.2 equivalents) was added to a 0.2 M solution of 7-benzyl-4-chloro-3-nitroquinoline or 6-benzyl-4-chloro-3-nitroquinoline (1 equivalent) and triethylamine (3 equivalents) in dichloromethane, and the reaction was stirred overnight at ambient temperature. The volatiles were removed under reduced pressure, and the residue was stirred with water (50 mL) for one hour. The resulting yellow solid was isolated by filtration and washed with water to provide 1-(7-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol or 1-(6-benzyl-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol, respectively.

출처