반응 #955141

반응 방정식

compound 2

2-(1H-Imidazol-1-yl)-N-methyl-1-(2-naphthalenyl)ethanimine N-oxide

phenyl allyl ether

→

3-(1H-Imidazol-1-ylmethyl)-2-methyl-3-(2-naphthalenyl)-5-(phenoxymethyl)isoxazolidine

용매

toluene

반응 조건

후처리

1. 1
   온도is refluxed for 48 hours
2. 2
   온도cooled
3. 3
   기타evaporated under vacuum
4. 4
   기타is crystallized from ether
5. 5
   기타recrystallized from ethyl acetate
6. 6
   기타to give tan crystals

실험 절차

A mixture of compound 2 (9.0 g, 0.034 mol) and phenyl allyl ether (6.98 ml, 0.051 mol) in 200 ml of toluene is refluxed for 48 hours, cooled and evaporated under vacuum. The semisolid that remained (7.30 g, 54%) is crystallized from ether and recrystallized from ethyl acetate to give tan crystals. Yield: 2.4 g (18%); m.p. 176°-178° C. (Found: C, 74.96; H, 6.41; N, 10.40. C25H25N3O2 requires: C, 75.16; H, 6.31; N, 10.52).

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