반응 #955
ord-38cb457f7729445685e412a4fffa8894
반응 방정식
4-hydroxyethyl piperidine
N-benzyloxycarbonyl-S-methyl isothiourea
→
title compound
수율 41.0%
1-Benzyloxycarbonylamidino-4-hydroxyethyl piperidine
수율 41.0%
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1온도was refluxed overnight
- 2기타Evaporation and flash chromatography on silica gel with ethyl acetate
실험 절차
A mixture of 6.2 g (0.028 mol) of 4-hydroxyethyl piperidine and 3.6 g (0.028 mol) of N-benzyloxycarbonyl-S-methyl isothiourea in 50 ml of acetonitrile was refluxed overnight. Evaporation and flash chromatography on silica gel with ethyl acetate gave 3.5 g (41%) of the title compound.