반응 #95495

반응 방정식

ether

6-chloro-1-(2-chlorophenyl)-1'-methylspiro[indoline-3,4'-piperidine]

phenyl chloroformate

→

6-chloro-1-(2-chlorophenyl)-1'-phenoxycarbonylspiro[indoline-3,4'-piperidine]

용매

methylene chloride

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후처리

1. 1
   세척Thereafter, the mixture is successively washed with 10% sodium hydroxide
2. 2
   세척washed with water
3. 3
   기타dried
4. 4
   농축concentrated under vacuum
5. 5
   기타leaving a brownish oil

실험 절차

A mixture of 0.8 g of 6-chloro-1-(2-chlorophenyl)-1'-methylspiro[indoline-3,4'-piperidine], free base of Example 28, and 0.5 g of phenyl chloroformate in 20 ml of methylene chloride is stirred at ambient temperature for 16 hours. Thereafter, the mixture is successively washed with 10% sodium hydroxide, washed with water, dried and concentrated under vacuum leaving a brownish oil. The oil is passed through an alumina column, ether eluant, providing a colorless gum of 6-chloro-1-(2-chlorophenyl)-1'-phenoxycarbonylspiro[indoline-3,4'-piperidine]. IR and NMR spectra confirm the assigned structure.

출처