반응 #95488

반응 방정식

1-(4-chlorophenyl)-1'-methylspiro[indoline-3,4'-piperidine]

cyanogen bromide

potassium carbonate

→

1-(4-chlorophenyl)-1'-cyanospiro[indoline-3,4'-piperidine]

용매

dichloromethane

반응 조건

후처리

1. 1
   여과The reaction mixture is filtered
2. 2
   농축the filtrate concentrated to dryness
3. 3
   기타leaving an oily residue which
4. 4
   기타is crystallized from an acetone-hexane mixture

실험 절차

A mixture of 0.95 g of 1-(4-chlorophenyl)-1'-methylspiro[indoline-3,4'-piperidine] (Example 2), 0.42 g of cyanogen bromide and 1 g of potassium carbonate in 25 ml of dichloromethane is stirred at ambient temperature for two hours. The reaction mixture is filtered and the filtrate concentrated to dryness leaving an oily residue which is crystallized from an acetone-hexane mixture leaving colorless crystals, mp 178.5°-180° C. of 1-(4-chlorophenyl)-1'-cyanospiro[indoline-3,4'-piperidine].

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