반응 #95463

반응 방정식

2-acetyl-6-(trimethylsilyl)-5-hexynoic acid ethyl ester

sodium hydride

→

2-acetyl-2-fluoro-6-(trimethylsilyl)-5-hexynoic acid ethyl ester

용매

toluene

반응 조건

후처리

1. 1
   온도the reaction mixture was cooled to -10°
2. 2
   기타was bubbled through the reaction mixture at such a rate that the internal temperature never exceeded 0° C
3. 3
   workup.ADDITIONThe perchloryl fluoride addition
4. 4
   기타Argon was bubbled through the mixture as it
5. 5
   기타The reaction mixture was partitioned between hexane and water
6. 6
   기타the organic phase was dried
7. 7
   기타(MgSO4) and condensed
8. 8
   기타by rotary evaporation
9. 9
   기타to give an oil
10. 10
    기타The components of the oil were separated by silica gel chromatography

실험 절차

2-acetyl-6-(trimethylsilyl)-5-hexynoic acid ethyl ester (7.1 g) was added to a suspension of sodium hydride (1.0 g) in toluene under a positive argon atmosphere. After stirring for 1 hour, the reaction mixture was cooled to -10° and a mixture of perchloryl fluoride and argon gases was bubbled through the reaction mixture at such a rate that the internal temperature never exceeded 0° C. The perchloryl fluoride addition was discontinued when it ceased to be exothermic. Argon was bubbled through the mixture as it was allowed to warm to room temperature. The reaction mixture was partitioned between hexane and water and the organic phase was dried (MgSO4) and condensed by rotary evaporation to give an oil. The components of the oil were separated by silica gel chromatography using 30% ethyl acetate/hexane as the eluant to give 5.9 g of 2-acetyl-2-fluoro-6-(trimethylsilyl)-5-hexynoic acid ethyl ester. There was also obtained 0.25 g of 2-fluoro-6-(trimethylsilyl)-5-hexynoic acid ethyl ester.

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