반응 #9540

반응 방정식

7-Bromo-4-chloro-3-nitroquinoline

4-(2-aminoethyl)-1-(tert-butoxycarbonyl)piperazine

→

tert-butyl 4-[2-(7-bromo-3-nitroquinolin-4-ylamino)ethyl]piperazine-1-carboxylate

수율 59.8%

반응 조건

후처리

1. 1
   기타The crude product was triturated with diethyl ether
2. 2
   기타isolated by filtration

실험 절차

7-Bromo-4-chloro-3-nitroquinoline (33.0 g, 115 mmol) was treated with 4-(2-aminoethyl)-1-(tert-butoxycarbonyl)piperazine (26.4 mL, 115 mmol) according to the method described in Part E of Example 1. The reaction was stirred overnight. The crude product was triturated with diethyl ether and isolated by filtration to provide 33.05 g of tert-butyl 4-[2-(7-bromo-3-nitroquinolin-4-ylamino)ethyl]piperazine-1-carboxylate as a yellow solid.

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