반응 #95354

반응 방정식

4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine mono-hydrochloride

α-bromo-p-chloroacetophenone

triethylamine

→

desired product

수율 56.0%

1-(4-Chlorobenzoylmethyl)-4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine

수율 56.0%

용매

methanol

반응 조건

후처리

1. 1
   기타The white crystals deposited are separated by filtration
2. 2
   세척successively washed with methanol and water
3. 3
   기타dried
4. 4
   기타to obtain 5.17 g of a crude product
5. 5
   기타The crude product is recrystallized from a mixed solvent of chloroform and ethanol

실험 절차

In this example, 4.0 g of 4-[3,4-dihydro-2(1H)-quinazolinon-3-yl]-piperidine mono-hydrochloride, 3.5 g of α-bromo-p-chloroacetophenone, 4.2 ml of triethylamine and 60 ml of methanol are mixed and stirred at room temperature overnight. The white crystals deposited are separated by filtration, successively washed with methanol and water and dried to obtain 5.17 g of a crude product. The crude product is recrystallized from a mixed solvent of chloroform and ethanol to obtain 3.21 g of the desired product.

출처