반응 #95327

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Pyridinium p-toluenesulfonate

(24R)-5,7-cholestadiene-3β,24,25-triol 3-tetrahydropyranyl ether

→

(24R)-5,7-cholestadiene-3β,24,25-triol

수율 67.3%

용매

ethanol

반응 조건

후처리

1. 1
   workup.WAITthe mixture was left
2. 2
   기타The reaction mixture was evaporated with 40 ml of ethyl acetate
3. 3
   세척The organic layer was washed with saturated brine
4. 4
   건조dried over anhydrous sodium sulfate
5. 5
   기타The solvent was evaporated under reduced pressure

실험 절차

Pyridinium p-toluenesulfonate (12.5 mg) was added to a solution of (24R)-5,7-cholestadiene-3β,24,25-triol 3-tetrahydropyranyl ether (25 mg) in 2 ml of ethanol in an argon stream under stirring, and the mixture was left to stand at room temperature for 2 days. The reaction mixture was evaporated with 40 ml of ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give 14 mg (67%) of (24R)-5,7-cholestadiene-3β,24,25-triol.

출처