반응 #953096

반응 방정식

water

N-hydroxysuccinimide

6-heptyloxy-2-naphthoic acid

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

→

succinimido 6-heptyloxy-2-naphthoate

수율 79.5%

용매

methylene chloride

반응 조건

후처리

1. 1
   기타The organic layer was separated
2. 2
   건조dried over magnesium sulfate
3. 3
   여과Magnesium sulfate was filtered off
4. 4
   기타the filtrate was evaporated under reduced pressure

실험 절차

To a susupension of N-hydroxysuccinimide (0.56 g) and 6-heptyloxy-2-naphthoic acid (1.39 g) in methylene chloride (42 ml) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (1.21 g) and stirred for 3 hours at room temparature. The reaction mixture was added to water (100 ml). The organic layer was separated and dried over magnesium sulfate. Magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give succinimido 6-heptyloxy-2-naphthoate (1.48 g).

출처