반응 #952393

반응 방정식

Sodium hydrogen sulfide monohydrate

3-(3-chloro-1,2,5-thiadiazol-4-yl)pyridine

Potassium carbonate

6-bromocapronitrile

→

title compound

3-(3-(5-Cyanopentylthio)-1,2,5-thiadiazol-4-yl)pyridine

용매

DMF

Water

반응 조건

후처리

1. 1
   workup.STIRRINGthe reaction mixture was stirred for additionally 24 h
2. 2
   추출extracted with ether
3. 3
   건조The combined ether phases were dried
4. 4
   기타evaporated

실험 절차

Sodium hydrogen sulfide monohydrate (0.25 g, 3.3 mmol) was added to a solution of 3-(3-chloro-1,2,5-thiadiazol-4-yl)pyridine (0.59 g, 3.0 mmol) in DMF (20 ml) at room temperature and the reaction mixture was stirred for 1 h. Potassium carbonate (1.24 g, 9 mmol) and 6-bromocapronitrile (0.80 g, 4.5 mmol) were added and the reaction mixture was stirred for additionally 24 h. Water (50 ml) was added and extracted with ether. The combined ether phases were dried and evaporated to give the title compound.

출처