반응 #951237

반응 방정식

6-fluoro-2-hydroxy-methylene-1-indanone

(RS)-1-hydrazino-2-propanol

water

toluene

→

(RS)-1-(7-fluoro-1,4-dihydro-indeno[2,1-c]pyrazol-1-yl)-propan-2-ol

수율 81.0%

반응 조건

후처리

1. 1
   농축After concentration in a vacuum
2. 2
   기타the reaction mixture was purified by column chromatography on silica gel (ethyl acetate)

실험 절차

A solution of 1.42 g (8.0 mmol) of 6-fluoro-2-hydroxy-methylene-1-indanone, 0.87 g (9.65 mmol) of (RS)-1-hydrazino-2-propanol and 100 mg of p-toluenesulfonic acid in 100 ml of anhydrous toluene was heated on a water separator for 1.5 hours. After concentration in a vacuum, the reaction mixture was purified by column chromatography on silica gel (ethyl acetate). 1.5 g (81%) of (RS)-1-(7-fluoro-1,4-dihydro-indeno[2,1-c]pyrazol-1-yl)-propan-2-ol were obtained as a yellow solid which was used directly in the next reaction.

출처