반응 #951200

반응 방정식

4-[3-(2-aminobenzoylamino)propylthio]pyridine

1,1'-thiocarbonyldiimidazole

→

desired product

수율 68.5%

3-[3-(4-pyridylthio)propyl]-quinazoline-2(1H)-thion-4(3H)-one

수율 68.5%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   workup.DISTILLATIONThe solvent was distilled off
2. 2
   세척the residue was washed with chloroform/ether

실험 절차

Under nitrogen atmosphere, to a solution of 1.48 g (5.15 mmol) of 4-[3-(2-aminobenzoylamino)propylthio]pyridine in 30 ml of tetrahydrofuran, 1.84 g (10.3 mmol) of 1,1'-thiocarbonyldiimidazole was added, and the mixture was stirred at room temperature for 64 hours. The solvent was distilled off and the residue was washed with chloroform/ether to give 1.16 g of the desired product (68.5% yield, pale brown crystals).

출처