반응 #95104

반응 방정식

5-(2-ethoxycarbonyl-5-benzyloxy-3-phenyl-1H-indole-1-yl)-valeric acid ethylester

ethanol

→

2-Benzyloxy-7,8,9,10-tetrahydro-10-oxo-11-phenyl-6H-9-azepino-[1,2-a]indole carboxylic acid ethylester

용매

toluene

toluene

반응 조건

후처리

1. 1
   workup.DISTILLATIONwas distilled off with toluene
2. 2
   온도After cooling
3. 3
   workup.ADDITIONice-cold dilute hydrochloric acid was added
4. 4
   추출the mixture was extracted with toluene
5. 5
   기타The toluene extracts were evaporated
6. 6
   기타the residue was purified by chromatography on silicagel (solvent: toluene)

실험 절차

Twenty-three grams (46 m mole) of 5-(2-ethoxycarbonyl-5-benzyloxy-3-phenyl-1H-indole-1-yl)-valeric acid ethylester were dissolved in 150 ml of toluene and added dropwise within four hours to a boiling suspension of 5.2 g (46 m mole) of potassium-tert.-butylate in 150 ml of toluene. Then the ethanol formed was distilled off with toluene. After cooling, ice-cold dilute hydrochloric acid was added and the mixture was extracted with toluene. The toluene extracts were evaporated, and the residue was purified by chromatography on silicagel (solvent: toluene).

출처