반응 #95103

반응 방정식

5-bromo-valeric acid ethylester

5-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester

sodium hydride

→

5-(2-Ethoxycarbonyl-5-benzyloxy-3-phenyl-1H-indole-1-yl)-valeric acid-ethylester

용매

dimethylformamide

반응 조건

후처리

1. 1
   기타After evaporation
2. 2
   기타the residue obtained
3. 3
   기타was chromatographed on silicagel (solvent: toluene/acetone (20.1))

실험 절차

An amount of 23.5 g (63.3 m mole) of 5-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester in absolute dimethylformamide was mixed with 3.0 g (63.3 m mole) of 50% sodium hydride. After 30 minutes, 13.2 g (63.3 m mole) of 5-bromo-valeric acid ethylester were added, and the mixture was stirred for three days. After evaporation, the residue obtained was chromatographed on silicagel (solvent: toluene/acetone (20.1)).

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