반응 #951020

반응 방정식

N-trityl-2-[4-(benzoxazol-2-yl)benzyloxy]ethylamine

HCl EtOH

→

2-[4-(benzoxazol-2-yl)benzyloxy]ethylamine hydrochloride

용매

EtOH

반응 조건

후처리

1. 1
   온도The reaction mixture is then cooled
2. 2
   여과the solid is filtered
3. 3
   세척washed with EtOH

실험 절차

N-trityl-2-[4-(benzoxazol-2-yl)benzyloxy]ethylamine (9.1 g; 17.8 mmol) is suspended in EtOH and treated with HCl/EtOH until acidic by pH paper. The reaction mixture is heated at 80° C. for 3 hours keeping the reaction acidic. The reaction mixture is then cooled and the solid is filtered and washed with EtOH to give 2-[4-(benzoxazol-2-yl)benzyloxy]ethylamine hydrochloride (m.p. 232°-233° C.) as a white solid which is used directly in Step F.

출처