반응 #95100

반응 방정식

2-bromo-propiophenone

4-benzyloxy-aniline

→

5Benzyloxy-3-methyl-2-phenyl-1H-indole

용매

triethylamine

반응 조건

후처리

1. 1
   기타The mixture was evaporated to dryness
2. 2
   온도the residue was heated for two hours to 180° C
3. 3
   온도After cooling
4. 4
   workup.ADDITIONthe residue was mixed with 10% hydrochloric acid
5. 5
   추출extracted with chloroform
6. 6
   건조The extracts were dried over sodium sulfate
7. 7
   여과filtered
8. 8
   기타evaporated
9. 9
   기타The residue obtained
10. 10
    기타was purified by column chromatography on silicagel with toluene as solvent

실험 절차

An amount of 3.6 g (0.015 mole) of 2-bromo-propiophenone and 6 g (0.03 mole) of 4-benzyloxy-aniline were refluxed for two hours in 15 ml of triethylamine. The mixture was evaporated to dryness, and the residue was heated for two hours to 180° C. After cooling, the residue was mixed with 10% hydrochloric acid and extracted with chloroform. The extracts were dried over sodium sulfate, filtered, and evaporated. The residue obtained was purified by column chromatography on silicagel with toluene as solvent.

출처