반응 #950789

반응 방정식

5-acetoxy-3-bromomethyl-2,3-dihydro-2,2,4,6,7-pentamethyl-1-benzofuran

potassium phthalimide

Water

→

2,3-dihydro-2,2,4,6,7-pentamethyl-3-phthalimidomethyl-1-benzofuran-5-ol acetate

용매

dimethylformamide

반응 조건

후처리

1. 1
   추출the product is extracted twice with ethyl ether
2. 2
   세척The extract is washed with water and brine
3. 3
   건조is dried over anhydrous sodium sulfate
4. 4
   여과After filtration, evaporation of the solvent
5. 5
   기타leaves a residue that
6. 6
   기타is crystallized from ethyl acetate/heptane

실험 절차

A mixture of 4.75 g of 5-acetoxy-3-bromomethyl-2,3-dihydro-2,2,4,6,7-pentamethyl-1-benzofuran (see Example 3) and 2.58 g (1 equivalent)of potassium phthalimide in 50 ml of dry dimethylformamide is stirred at 60° C. for 48 hours. Water is added and the product is extracted twice with ethyl ether. The extract is washed with water and brine, and is dried over anhydrous sodium sulfate. After filtration, evaporation of the solvent leaves a residue that is crystallized from ethyl acetate/heptane. The first crop contains free phthalimide, but subsequent crops yield 2,3-dihydro-2,2,4,6,7-pentamethyl-3-phthalimidomethyl-1-benzofuran-5-ol acetate.

출처