반응 #9505

반응 방정식

N1-(3-nitro-7-phenylquinolin-4-yl)-2-methylpropane-1,2-diamine

Cyclohexyl isocyanate

→

N-cyclohexyl-N′-[1,1-dimethyl-2-(3-nitro-7-phenylquinolin-4-ylamino)ethyl]urea

용매

dichloromethane

반응 조건

후처리

1. 1
   기타The solvent was removed under reduced pressure
2. 2
   workup.ADDITIONXylenes (3 cx 100 mL) were added
3. 3
   기타removed under reduced pressure

실험 절차

A solution of N1-(3-nitro-7-phenylquinolin-4-yl)-2-methylpropane-1,2-diamine (3.56 g, 10.6 mmol) in dichloromethane (100 mL) was cooled to 0° C. Cyclohexyl isocyanate (3.00 mL, 23.5 mmol) was added over the course of a day, and the reaction was stirred at ambient temperature for three days. The solvent was removed under reduced pressure. Xylenes (3 cx 100 mL) were added and removed under reduced pressure to provide N-cyclohexyl-N′-[1,1-dimethyl-2-(3-nitro-7-phenylquinolin-4-ylamino)ethyl]urea as a yellow solid.

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