반응 #95017

반응 방정식

2,3-dichloropyrazine

methanol

product

2-Amino-3-bromo-5-methylpyrazine

→

2-amino-3-n-propoxy-5-methylpyrazine

용매

n-propanol

반응 조건

후처리

1. 1
   기타described in Preparation 43

실험 절차

By replacing the 2,3-dichloropyrazine and anhydrous methanol used in Preparation 43 by equivalent quantities of the product of Step A and n-propanol and following the method described in Preparation 43, 2-amino-3-n-propoxy-5-methylpyrazine is obtained. The 2-amino group can be converted to the 2-hydroxy by the method described by Sharp et al, ibid., (see Route III) which when treated with phosphorus oxychloride by the method of Preparation 13, Step B, provides 2-chloro-3-n-propoxy-5-methylpyrazine.

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