반응 #95003

반응 방정식

4-hydroxy-6-methyl-2-trichloromethylpyrimidine

potassium carbonate

pyrrolidinecarbonyl chloride

→

residue

수율 125.8%

6-Methyl-4-(1-Pyrrolidinylcarboxy)-2-Trichloromethylpyrimidine

수율 125.8%

용매

acetone

반응 조건

후처리

1. 1
   온도was refluxed 5.3 hours
2. 2
   여과A precipitate was filtered out
3. 3
   기타the filtrate rotary evaporated

실험 절차

A mixture of 5.8 g (0.027 mole) 4-hydroxy-6-methyl-2-trichloromethylpyrimidine, 3.3 g (0.024 mole) potassium carbonate, 3.2 g (0.024 mole) pyrrolidinecarbonyl chloride, and 100 ml acetone was refluxed 5.3 hours. A precipitate was filtered out and the filtrate rotary evaporated to give 9.8 g residue. This was taken up in chloroform, the solution washed with 1% sodium hydroxide, water, and dried over anhydrous magnesium sulfate. Rotary evaporation yielded 4.4 g residue which was recrystallized from petroleum ether to give 2.2 g (28% yield; mp 93°-95° C.) of product. The structure was confirmed via infrared and elemental analysis.

출처