반응 #95002

반응 방정식

4-hydroxy-6-methyl-2-trichloromethylpyrimidine

potassium carbonate

dimethylcarbamoyl chloride

acetone

→

residue

6-Methyl-2-Trichloromethyl-4-Pyrimidinyl Diethylcarbamate

반응 조건

후처리

1. 1
   온도was refluxed 5 hours
2. 2
   여과A precipitate was filtered out
3. 3
   기타the filtrate rotary evaporated

실험 절차

A mixture of 5.8 g (0.027 mole) 4-hydroxy-6-methyl-2-trichloromethylpyrimidine, 3.3 g (0.024 mole) potassium carbonate, 3.3 g (0.024 mole) dimethylcarbamoyl chloride, and 100 ml acetone was refluxed 5 hours. A precipitate was filtered out and the filtrate rotary evaporated to give 10.2 g residue. This was taken up in chloroform, the solution washed with 1% sodium hydroxide, water, and dried over anhydrous magnesium sulfate. Rotary evaporation yielded 5.2 g residue which was recrystallized from petroleum ether to give 2.1 g (24% yield) of product. An analytical sample recrystallized a second time from petroleum ether had mp 77°-77.5° C. The structure was confirmed via infrared and elemental analysis.

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