반응 #95001

반응 방정식

6-chloromethyl-4-hydroxy-2-trichloromethylpyrimidine

triethylamine

dimethylcarbamoyl chloride

→

pure product

수율 60.1%

6-Chloromethyl-2-Trichloromethyl-4-Pyrimidinyl Dimethylcarbamate

수율 60.1%

용매

ether

반응 조건

후처리

1. 1
   기타The solvent was rotary evaporated
2. 2
   추출the residue extracted with refluxing ligroin
3. 3
   온도The extract was cooled

실험 절차

A solution of 1.3 g (0.005 mole) 6-chloromethyl-4-hydroxy-2-trichloromethylpyrimidine, 0.55 g (0.005 mole) triethylamine, 0.55 g (0.005 mole) dimethylcarbamoyl chloride and 25 ml ether was refluxed 20 hours. The solvent was rotary evaporated and the residue extracted with refluxing ligroin. The extract was cooled to yield 1.0 g (60% yield) of pure product as a thick oil. The structure was confirmed via infrared and elemental analysis.

출처