반응 #95000

반응 방정식

trichloroacetamidine

potassium carbonate

ethyl-4-chloroacetoacetate

→

crude product

수율 36.1%

6-Chloromethyl-4-Hydroxy-2-Trichloromethylpyrimidine

수율 36.1%

용매

water

반응 조건

후처리

1. 1
   여과The aqueous solution was filtered
2. 2
   기타to give a precipitate
3. 3
   세척The precipitate was washed
4. 4
   기타dried

실험 절차

A mixture of 30.0 g (0.18 mole) trichloroacetamidine, 25.2 g (0.18 mole) potassium carbonate, 30.3 g (0.18 mole) ethyl-4-chloroacetoacetate and 400 ml water was stirred 18 hours. The aqueous solution was filtered and acidified with hydrochloric acid to give a precipitate. The precipitate was washed and dried to give 17.0 g (36% yield) of crude product. An analytical sample recrystallized from ligroin had mp 138°-144° C. The structure was confirmed via infrared and elemental analysis.

출처