반응 #94995

반응 방정식

4-hydroxy-6-methyl-2-trichloromethylpyrimidine

triethylamine

dimethylcarbamoyl chloride

→

6-Methyl-2-Trichloromethyl-4-Pyrimidinyl Dimethylcarbamate

수율 48.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   workup.STIRRINGThe reaction mixture was stirred 2 hours
2. 2
   온도under reflux
3. 3
   온도to cool
4. 4
   여과A solid was filtered out
5. 5
   온도after cooling
6. 6
   세척washed with water
7. 7
   기타to give 3.6 g (48% yield; mp 83.5°-84.5° C.)

실험 절차

A mixture of 5.7 g (0.025 mole) 4-hydroxy-6-methyl-2-trichloromethylpyrimidine, 5.1 g (0.05 mole) triethylamine, and 100 ml acetonitrile was stirred and 5.4 g (0.05 mole) dimethylcarbamoyl chloride was added to the mixture. The reaction mixture was stirred 2 hours under reflux, and allowed to cool. A solid was filtered out after cooling and washed with water to give 3.6 g (48% yield; mp 83.5°-84.5° C.). The structure was confirmed via infrared and elemental analysis.

출처