반응 #94994

반응 방정식

trichloroacetamidine

methylacetoacetate

potassium carbonate

→

4-Hydroxy-6-Methyl-2-Trichloromethylpyrimidine

수율 46.0%

용매

water

반응 조건

후처리

1. 1
   기타A trace of solid was removed by filtration
2. 2
   기타The product precipitated out
3. 3
   기타to give 28.9 g (46% yield; mp 173°-174° C.)

실험 절차

A mixture of 44.4 g (0.28 mole) trichloroacetamidine, 32.0 g (0.28 mole) methylacetoacetate, 37.5 g (0.28 mole) potassium carbonate, and 450 ml water was stirred for 3 days. A trace of solid was removed by filtration and the filtrate was made acidic with hydrochloric acid. The product precipitated out to give 28.9 g (46% yield; mp 173°-174° C.). The structure was confirmed via mp*, infrared and elemental analysis.

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