반응 #948828

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16α-Bromo-3β-methylandrost-5-en-17-one

Sodium hydroxide

HCl

→

16α-hydroxy-3β-methylandrost-5-en-17-one

수율 65.2%

용매

dimethylformamide

water

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate (2×50 mL)
2. 2
   세척The organic layer was washed with 5% sodium biocarbonate, water
3. 3
   건조dried over magnesium sulfate
4. 4
   여과filtered
5. 5
   기타Evaporation
6. 6
   기타gave a pale yellow solid which
7. 7
   기타was chromatographed on flash silica gel
8. 8
   세척eluted with ether/hexane (10/90)
9. 9
   기타Recrystallization from ether

실험 절차

16α-Bromo-3β-methylandrost-5-en-17-one (1.00 g, 2.74 ,mmol) was dissolved in dimethylformamide (90 mL). Sodium hydroxide (165 mg, 4.1 mmol) in water (10 mL) was added and the solution stirred for 2 h. at room temperature. The solution was poured into 1% HCl (200 mL) and extracted with ethyl acetate (2×50 mL). The organic layer was washed with 5% sodium biocarbonate, water, then dried over magnesium sulfate and filtered. Evaporation gave a pale yellow solid which was chromatographed on flash silica gel and eluted with ether/hexane (10/90). Recrystallization from ether gave 0.54 g (65%) 16α-hydroxy-3β-methylandrost-5-en-17-one mp 166°-168° C.; NMR (DMSO-d6) δ 5.30 (br s, 1H, H-3), 4.38 (t, 1H, 16β-H), 2.0-1.05 (m, complex), 0.98 (s, 3H, C-19 Me), 0.95 (d, J=8 Hz, 3H, C-3 Me), 0.87 (s, 3H, C-18 Me); IR (KBr) 3440, 2900, 1735, 1445, 1365, 1010; MS 302 (m+, 100), 287(24), 274(7), 259(7), 241(7), 230(72), 215(41), 159(31); Anal. Calcd for C20 H30O2 : C, 79.42; H, 9.99. Found: C, 79.24; H, 10.04.

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