반응 #94863

반응 방정식

methyl 3-acetylsalicylate

potassium carbonate

α-bromo-γ-butyrolactone

→

α-[(6-acetyl-2-methoxycarbonylphenyl)oxy]-γ-butyrolactone

용매

acetone

반응 조건

후처리

1. 1
   온도the mixture was refluxed for 11 hours
2. 2
   여과The insolubles were filtered off
3. 3
   농축the filtrate was concentrated under reduced pressure

실험 절차

To a mixture of methyl 3-acetylsalicylate (5.8 g) and potassium carbonate (10.4 g) in acetone (200 ml) was added α-bromo-γ-butyrolactone (12.5 g) under stirring, and the mixture was refluxed for 11 hours. The insolubles were filtered off and the filtrate was concentrated under reduced pressure. The residue was subjected to chromatography on silica gel eluting with chloroform. By the above procedure, there was obtained α-[(6-acetyl-2-methoxycarbonylphenyl)oxy]-γ-butyrolactone as pale yellow oil.

출처