반응 #948368

반응 방정식

N4 -acetyl-N1 -hexanoylsulfanilamide

N4 -acetylsulfanilamide

hexanoyl chloride

HCl

→

N1 -hexanoylsulfanilamide

용매

pyridine

water

반응 조건

후처리

1. 1
   workup.ADDITIONby diluting with 600 mL D.I
2. 2
   기타was isolated by filtration
3. 3
   세척washed with D.I
4. 4
   기타water (700 mL) to afford an off-white solid

실험 절차

N1 -hexanoylsulfanilamide was prepared as follows. To a mixture of N4 -acetylsulfanilamide (55.0 g) and pyridine (54 mL) at 95° C. was added hexanoyl chloride (28.8 g) over a period of 20 min. After an additional hour the reaction mixture was cooled to room temperature and the reaction was worked up by diluting with 600 mL D.I. water and acidifying with aqueous HCl. The product of this reaction, N4 -acetyl-N1 -hexanoylsulfanilamide, was isolated by filtration and washed with D.I. water (700 mL) to afford an off-white solid. This material was carried directly to the next step.

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