반응 #94831

반응 방정식

6-propyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

n-butyl bromide

potassium hydroxide

→

3-n-butyl-6-propyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine

용매

methanol

반응 조건

후처리

1. 1
   온도refluxed for 48 hours
2. 2
   기타The reaction mixture is evaporated to dryness
3. 3
   여과filtered
4. 4
   기타to remove inorganic salts
5. 5
   세척The filtrate is washed with water
6. 6
   기타dried
7. 7
   기타evaporated

실험 절차

A mixture of 4.5 g of 6-propyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, 0.02 mole of n-butyl bromide and 0.02 mole of potassium hydroxide is dissolved in 120 ml of dry methanol and refluxed for 48 hours. The reaction mixture is evaporated to dryness, taken up in ethyl acetate and filtered to remove inorganic salts. The filtrate is washed with water, dried and evaporated to give 3-n-butyl-6-propyl-7,8-dimethoxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine.

출처