반응 #94828
ord-4e98e46d8be14dc0b62c0c3aef402f49
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반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타is brought to 20°-25°
- 2기타The layers are separated
- 3추출the aqueous layer is extracted with methylene chloride (2×5 ml)
- 4세척washed with water (10 ml)
- 5건조dried over sodium sulfate
- 6농축concentrated under reduced pressure
실험 절차
To a solution of 21-chloro-20-methoxy-21-(phenylsulfinyl)pregna-4,9(11),17(20)-trien-3-one (VI, Example 3, 100 mg) in THF (2 ml), methanol (0.45 ml) and acetone (0.3 ml) at 0° under nitrogen is added a solution of sodium hydroxide (5 N, 0.04 ml). The mixture is brought to 20°-25° and is allowed to stir for 24 hr. The mixture is poured into a mixture of water (25 ml) and methylene chloride (10 ml). The layers are separated and the aqueous layer is extracted with methylene chloride (2×5 ml). The organic extracts are combined and washed with water (10 ml), dried over sodium sulfate and concentrated under reduced pressure to give the title compound.