반응 #948246

ord-7ddb0354334c4188a88a8fccaeb6315a

반응 방정식

COC(=O)c1cccc(C)c1
methyl 3-methylbenzoate
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C)C(C)C
A-208
O=C(Cc1ccncc1)c1ccc(F)cc1
4-fluorobenzoyl-4-pyridinyl methane
Cc1ccncn1
4-methyl-pyrimidine
→
Cc1cccc(-c2n[nH]cc2-c2ccncn2)c1
4-[3-(3-methylphenyl)-1H-pyrazol-4-yl]pyrimidine

반응물

COC(=O)c1cccc(C)c1
methyl 3-methylbenzoate
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C)C(C)C
A-208
—
1-methyl-3-(4′-pyrimidinylacetyl)benzene
O=C(Cc1ccncc1)c1ccc(F)cc1
4-fluorobenzoyl-4-pyridinyl methane
Cc1ccncn1
4-methyl-pyrimidine

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타This compound was prepared by the same procedure
  2. 2
    기타prepared

실험 절차

This compound was prepared by the same procedure as described for Example A-208 except that 1-methyl-3-(4′-pyrimidinylacetyl)benzene (prepared as set forth in Step 1 of Example A-19 from 4-methyl-pyrimidine and methyl 3-methylbenzoate) was used in place of 4-fluorobenzoyl-4-pyridinyl methane.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07153959B2uspto-grants-2006_12