반응 #948153

반응 방정식

3,5-dibromo-4-(3-isopropyl-4-methoxyphenoxy)phenylacetic acid

benzyltrimethylammonium tetrachloroiodate

→

3,5-dibromo-4-(3-chloro-4-hydroxy-5-isopropylphenoxy)phenylacetic acid

수율 50.0%

용매

acetic acid

반응 조건

후처리

1. 1
   여과was filtered
2. 2
   농축The filtrate was concentrated
3. 3
   추출the product was extracted with ethyl acetate
4. 4
   세척washed with saturated NaHCO3 (aq), NaCl (aq)
5. 5
   건조dried over MgSO4
6. 6
   농축concentrated in vacuo
7. 7
   기타The residue was purified on column (silica gel, chloroform/methanol/acetic acid 98:2:0.3)

실험 절차

To a stirred solution of 3,5-dibromo-4-(3-isopropyl-4-methoxyphenoxy)phenylacetic acid (1.5 g, 3.4 mmol) in acetic acid (40 mL) at room temperature was added benzyltrimethylammonium tetrachloroiodate (1.42 g, 3.4 mmol). The reaction mixture was stirred for one hour and was filtered. The filtrate was concentrated, and the product was extracted with ethyl acetate, washed with saturated NaHCO3 (aq), NaCl (aq), and dried over MgSO4 and concentrated in vacuo. The residue was purified on column (silica gel, chloroform/methanol/acetic acid 98:2:0.3) to give 802 mg (50%) of 3,5-dibromo-4-(3-chloro-4-hydroxy-5-isopropylphenoxy)phenylacetic acid.

출처