반응 #9480

반응 방정식

Triethyl orthopropionate

1-(3-amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol

→

1-(7-bromo-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol

수율 74.9%

용매

toluene

반응 조건

후처리

1. 1
   온도the reaction was heated
2. 2
   온도at reflux for three hours
3. 3
   기타a precipitate formed
4. 4
   기타The precipitate was isolated by filtration
5. 5
   세척washed with toluene
6. 6
   기타air-dried

실험 절차

Triethyl orthopropionate (12.9 g, 73.2 mmol) and pyridine hydrochloride (220 mg) were added to a solution of 1-(3-amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol (22.1 g, 70.6 mmol) in anhydrous toluene (300 mL), and the reaction was heated at reflux for three hours. The reaction was allowed to cool to ambient temperature and stand overnight; a precipitate formed. The precipitate was isolated by filtration, washed with toluene, and air-dried to provide 18.42 g of 1-(7-bromo-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol as beige crystals.

출처