반응 #948

반응 방정식

2-amino-2-ethyl-1,3-propanediol

diethyl carbonate

EtOH

→

desired product

(+-)-Ethyl-4-(hydroxymethyl)-2-oxazolidinone

반응 조건

후처리

1. 1
   기타was collected
2. 2
   온도The reaction mixture was cooled
3. 3
   workup.ADDITIONadded acetone (200 ml)
4. 4
   기타to stand overnite at room temperature
5. 5
   여과The resulting suspension was filtered

실험 절차

Sodium methoxide (2.2 g, Aldrich) was added to a solution of 2-amino-2-ethyl-1,3-propanediol (100.0 g, Aldrich) and diethyl carbonate (169.0 g, Aldrich) This solution was refluxed in a Dean Stark apparatus until no more EtOH was collected. The reaction mixture was cooled, added acetone (200 ml) and allowed to stand overnite at room temperature. The resulting suspension was filtered to give 81.0 g of the desired product as a beige solid. 1H NMR consistent with the proposed structure.

출처