반응 #94760

ord-de4ce3fad7264a008d4de8ea7ef562bc

반응 방정식

CC(CC(=O)c1ccc(Cl)s1)C(=O)N1CCC[C@H]1C(=O)O
[S]-1-[3-(5-chloro-2-thenoyl)-2-methylpropionyl]-L-proline
CC([O-])=S.[Na+]
sodium thioacetate
→
CC(=O)SC(C(=O)c1ccc(Cl)s1)C(C)C(=O)N1CCC[C@H]1C(=O)O
1-[3-Acetylthio-3-(5-chloro-2-thenoyl)-2-methylpropionyl]-L-proline

반응물

CC(CC(=O)c1ccc(Cl)s1)C(=O)N1CCC[C@H]1C(=O)O
[S]-1-[3-(5-chloro-2-thenoyl)-2-methylpropionyl]-L-proline
CC([O-])=S.[Na+]
sodium thioacetate

시약

없음

용매

CC#N
acetonitrile

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타gives

실험 절차

Bromination of the [S]-1-[3-(5-chloro-2-thenoyl)-2-methylpropionyl]-L-proline and reaction of the brominated product with sodium thioacetate in acetonitrile gives a mixture of the [R-(R*,S*)] and [R-(R*,R*)] isomers of the product of the Example as a glass.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04342689uspto-grants-1982_08