반응 #9476

반응 방정식

1-(3-amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol

Ethoxyacetyl chloride

→

N-[7-bromo-4-(2-hydroxy-2-methylpropylamino)quinolin-3-yl]-2-ethoxyacetamide

용매

dichloromethane

반응 조건

후처리

1. 1
   기타A precipitate formed
2. 2
   기타was isolated by filtration

실험 절차

A solution of 1-(3-amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol (158.19 g, 0.510 mol) in dichloromethane (1.2 L) was cooled to 0° C. Ethoxyacetyl chloride (62.50 g, 0.510 mol) was added dropwise, and then the reaction was allowed to warm to ambient temperature and stirred overnight. A precipitate formed and was isolated by filtration to provide N-[7-bromo-4-(2-hydroxy-2-methylpropylamino)quinolin-3-yl]-2-ethoxyacetamide as a solid.

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