반응 #9475

반응 방정식

1-(7-bromo-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol

→

1-(3-amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol

수율 85.7%

용매

acetonitrile

반응 조건

후처리

1. 1
   기타for two days
2. 2
   여과The reaction mixture was filtered through a layer of CELITE
3. 3
   여과filter aid
4. 4
   세척the filter cake was washed with ethanol (1 L)
5. 5
   농축The filtrate was concentrated under reduced pressure

실험 절차

A solution of 1-(7-bromo-3-nitroquinolin-4-ylamino)-2-methylpropan-2-ol (27.78 g, 81.66 mmol) in acetonitrile (1.2 L) was added to a Parr vessel charged with 5% platinum on carbon (0.84 g), and the reaction was placed under hydrogen pressure (50 psi, 3.4×105 Pa) for two days. The reaction mixture was filtered through a layer of CELITE filter aid, and the filter cake was washed with ethanol (1 L). The filtrate was concentrated under reduced pressure to provide 21.70 g of 1-(3-amino-7-bromoquinolin-4-ylamino)-2-methylpropan-2-ol as a yellow oil.

출처